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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD6
All Species:
19.39
Human Site:
S294
Identified Species:
35.56
UniProt:
O43541
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43541
NP_001136333.1
496
53497
S294
E
Y
K
P
L
D
L
S
D
S
T
L
S
Y
T
Chimpanzee
Pan troglodytes
XP_523105
496
53474
S294
E
Y
K
P
L
D
L
S
D
S
T
L
S
Y
T
Rhesus Macaque
Macaca mulatta
XP_001104638
454
49165
S252
D
Y
K
P
L
D
L
S
D
S
T
L
S
Y
T
Dog
Lupus familis
XP_544737
499
53465
S295
E
Y
K
P
L
D
L
S
D
S
T
L
S
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
O35182
495
53696
S295
Q
Y
K
P
L
D
L
S
D
S
T
L
S
Y
T
Rat
Rattus norvegicus
O88406
426
46439
S232
C
P
D
A
V
P
S
S
D
E
T
G
G
T
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516238
280
31765
E87
T
L
S
Y
T
E
T
E
A
T
N
S
L
N
I
Chicken
Gallus gallus
Q9W734
431
47806
L232
L
D
L
S
D
S
T
L
S
Y
T
E
T
E
A
Frog
Xenopus laevis
NP_001091249
352
38824
I159
L
S
D
S
Y
T
E
I
E
A
S
N
S
L
W
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
Q240
A
S
D
Q
Q
M
N
Q
S
M
D
T
G
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
Q252
A
Q
M
G
D
V
A
Q
V
S
Y
S
E
P
A
Honey Bee
Apis mellifera
XP_396816
251
28007
P58
K
P
E
S
P
P
P
P
Y
C
L
I
A
D
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
E178
V
E
F
G
Q
S
T
E
T
G
N
T
P
T
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
90.7
94.9
N.A.
93.3
42.5
N.A.
44.3
67.5
51
23.7
N.A.
22.5
29.2
N.A.
38.9
Protein Similarity:
100
99.4
90.9
95.7
N.A.
94.3
54.2
N.A.
49.7
73.1
58
39.9
N.A.
38.9
34.4
N.A.
50.2
P-Site Identity:
100
100
93.3
100
N.A.
93.3
20
N.A.
0
6.6
6.6
0
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
13.3
13.3
26.6
0
N.A.
6.6
26.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
8
0
0
8
0
8
8
0
0
8
0
16
% A
% Cys:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
8
8
24
0
16
39
0
0
47
0
8
0
0
8
0
% D
% Glu:
24
8
8
0
0
8
8
16
8
8
0
8
8
8
8
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
16
0
0
0
0
0
8
0
8
16
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
8
% I
% Lys:
8
0
39
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
16
8
8
0
39
0
39
8
0
0
8
39
8
8
0
% L
% Met:
0
0
8
0
0
8
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
16
8
0
8
8
% N
% Pro:
0
16
0
39
8
16
8
8
0
0
0
0
8
8
8
% P
% Gln:
8
8
0
8
16
0
0
16
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
16
8
24
0
16
8
47
16
47
8
16
47
8
0
% S
% Thr:
8
0
0
0
8
8
24
0
8
8
54
16
8
16
39
% T
% Val:
8
0
0
0
8
8
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
39
0
8
8
0
0
0
8
8
8
0
0
39
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _